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TAZIT » 12 грудня 2020, 22:45
Выявлены генетические особенности , влияющие на тяжесть последствий заболевания КВ2019 ... .
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Genetic mechanisms of critical illness in Covid-19
Erola Pairo-Castineira, Sara Clohisey, […]J. Kenneth Baillie
Nature (2020)Cite this article
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Abstract
Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study(GWAS) in 2244 critically ill Covid-19 patients from 208 UK intensive care units (ICUs). We identify and replicate novel genome-wide significant associations, on chr12q24.13 (rs10735079, p=1.65 ×OAS3), on chr19p13.2 (rs2109069, p=2.3 ×××, and high expression of TYK2, to life-threatening disease; transcriptome-wide association in lung tissue revealed that high expression of the monocyte/macrophage chemotactic receptor CCR2 is associated with severe Covid-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms, and mediators of inflammatory organ damage in Covid-19. Both mechanisms may be amenable to targeted treatment with existing drugs. Large-scale randomised clinical trials will be essential before any change to clinical practice .